A One-Pot Transformation of Ketones Into N-(Meth)Acryloyl-2-Amino Acids
1987
Abstract A synthetic sequence for the preparation of N-(meth)acryloyl-2-amino acids is outlined which involves transformation of a ketone successively into an aminonitrile and a (meth)acrylamidonitrile, followed by selective hydrolysis of the nitrile function. All reactions are performed in aqueous media, in one reaction vessel, and in a stepwise manner without isolation of any intermediate products.
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