[Computed tomographic and angiographic studies of arterial liver perfusion following intra-arterial infusion chemotherapy using 5-fluoro-2-deoxyuridine].

: Fifty patients with liver metastases from colorectal primaries underwent hepatic intraarterial chemotherapy using 5-fluoro-2-deoxyuridine as an antitumour agent. Repeated computed tomography and angiography of the liver was performed during a follow-up period of a year. Following six months of regional chemotherapy, arterial perfusion abnormalities of the liver were detected in 40 of the total of 50 patients. After one year of intraarterial chemotherapy normal arterial liver perfusion was found in only two patients. Histology revealed thrombotic occlusion or narrowing of hepatic arteries, respectively.