Comparative Analgesic Activity of Selected Medicinal Plants from Pakistan

Pain is a natural self-protective system which is always unpleasant both mentally and physically withprobable tissue harm. Analgesics are the medicinal agents which relief the pain without losing consciousness.Medicinal plants are being widely used all over the world for human healthy life form. We selected ten Pakistani plantswhich play an important role as traditional medicine in the prevention and management of acute and chronic diseases.All plants were extracted with ethanol and have been investigated for analgesic effects using hotplate and writhingreflex tests in rats. Phytochemical screening revealed the presence of polyphenols, saponins, sugar, flavonoids, andalkaloid. In our research, the analgesic effect of selected medicinal plants shows significant effect like standard aspirinand diclophenic. The intake of these aforementioned phytochemical flavonoids and polyphenols are considered to beresponsible for pain management because they may contain many powerful antioxidant and free radical scavengingcapabilities which are the backbone of other bioactivities such as anti-inflammatory action, anticancer, anti-aging, andprotective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative disorders. In future,these plants may be utilized as a health benefit in view of their potential research in the prevention and managementof pain.