Effects of Lipoic Acid on Protecting in vitro Cultured Bovine Aortic Cells from Oxidative Damage

In order to reveal the potential function of lipoic acid(LA)in protecting cardiovascular system from oxidative damage,the effects of LA on cultured bovine aortic endothelial cells(EC) and smooth muscle cells(SMC) injured by H2O2 were investigated.The results showed that LA can dose-dependently promote the activities of superoxide dismutase(SOD) and decrease the level of malondialdehyde(MDA) in EC and SMC,indicating LA can effectively prevent EC and SMC from H2O2 induced oxidative damage.Our results can provide new free radical biological data for the further study on the medical and health-care use of LA.