Diode laser systems for photodynamic therapy

AlGaInP diode lasers generate optical output in a range of the spectrum suitable for the activation of several second=generation photosensitizers including tin ethyl etiopurpurin, SnET2. The development of a system suitable for this application entails coupling the output of multiple highly divergent and astigmatic sources into a single optical fiber for most applications. Various methods of fulfilling this requirement will be discussed along with the advantages and drawbacks of each method. The incorporation into the clinical laser system of on-line dosimetry control of the light delivery parameters will be described along with the results of biological equivalency studies.