Prediction of Hemorrhagic Transfor mation and Functional Outcome Using HAT Score in Acute Ischemic Stroke Patients Treated with Intravenous Alteplase

score for HT and symptomatic intracranial hemorrhage (sICH) was calculated using C statistics. Results: Among 151 consecutive patients, HT was confirmed in 35 on follow-up brain imaging. Atrial fibrillation (OR=2.709, 95%CI=1.118-6.567) and low one-third CT scan (OR=3.419, 95%CI=1.281-9.121) increased the risk of HT after intravenous thrombolysis in multivariate logistic regression analysis. HT, sICH (based on the National Institute of Neurological Disorders and Stroke and the Safe Implementation of Treatment in Stroke - Monitoring Study definitions), unfavorable (modified Rankin Scale (mRS) score of 2-6) and poor (mRS score of 3-6) outcomes at 3 months, and mortality at 3 months were increased with higher HAT scores (C statistic=0.632, 0.637, 0.843, 0.670, 0.689, and 0.659, respectively; p=0.018, 0.036, 0.042, 0.002, 0.015, and <0.001). Conclusions: The HAT score can be used to predict the risk of sICH following intravenous thrombolysis and the long-term clinical outcome. J Korean Neurol Assoc 30(2):110-115, 2012