Briaexcavatolides K−N, New Briarane Diterpenes from the Gorgonian Briareum excavatum

Four new briarane diterpenes, briaexcavatolides K-N (1-4), along with a known diterpene, 5, have been isolated from the Taiwanese gorgonian Briareum excavatum. The structures of the new metabolites were established by extensive spectral analyses. Furthermore, the structure, including the relative configuration of briaexcavatolide K (1), was confirmed by a single-crystal X-ray analysis. Briaexcavatolides K and L (1 and 2) are the only briarane diterpenes known to possess hydroxyl groups at the C-8β and C-17a positions, respectively. Cytotoxicity of these metabolites toward various cancer cell lines also is described.