Investigation of alternative supported liquid membranes in electromembrane extraction of basic drugs from human plasma

Abstract For the first time, supported liquid membranes (SLMs) of phthalate- and nitrile-based organic solvents were investigated for electromembrane extraction (EME) of eleven polar and non-polar basic drugs from human plasma (pH 7.4). Several phthalates and nitriles which possess high hydrogen bond acceptor basicity, zero hydrogen bond donor acidity, and certain level of hydrophobicity (3