Multifocal fungal infections in patients after renal transplantation undergoing immunosuppression

: The aim of the study was to estimate the prevalence of fungi in monofocal and multifocal infections in renal transplant recipients and the characteristics of 60 species and intraspecies features of fungal strains isolated from the organ ontocenoses: oral cavity, rectum and genital organs in 32 patients undergoing permanent immunosuppression after renal transplantation. Fungal strains were recovered in 66 out of 96 samples (68.2% off all renal transplant recipients). There were in ontocenoses: oral cavity (65.6%), rectum (37.5%) and genital organs (25.0%). Monofocals mycosis were found only in 21.9% of the patients. Multifocal infections occurred in 68.2% and contained ontocenoses of oral cavity and rectum (34.4%) the most frequently. Trifocal infection occurred in 12.5% of all examined renal transplant recipients. Fungal strains identified using API 20 C and API 20 C AUX (bioMerieux). The activity of 19 hydrolases was investigated using API ZYM. From among 41 strains of fungi the following were found: Candida albicans (31 strains), Candida glabrata (5), Candida guilliermondii (2), Candida krusei (2) and Saccharomyces cerevisiae (1). The enzymograms were described for all strains and the highest activity was noted in case of: leucine arylamidase, acid phosphatase, esterase, naphtol-AS-BI-phosphohydrolase. The presence high mean of activity of this enzymes means high pathogenicity of C. albicans strains.