Synthesis, Characterization, and Anticancer Activity of NovelMacrocyclic Indenedione Based on the Tröger’s Base and N,N′-Disubstituted PhenhomazineCandidates
2020
1,3-Indenedione has been reacted with p-aminobenzaldehyde to give the corresponding p-aminobenzylidine-1,3-indenedione, treatment of
which with paraformaldehyde and trifluroacetic acid has led to the Troger’s base
analogue. Treatment of that compound with dimethyl sulfate, acetic anhydride,
benzoyl chloride, or trifluroacetic anhydride can afford the correspondingN,N′-disubstituted phenhomazines. Complexation of the Troger’s base
with ferric nitrate trihydrate or nickel chloride hexahydrate has resulted in
the corresponding complexes. The structures of all compounds have been confirmed
by their elemental analyses and spectral data. All the newly synthesized
Troger’s base and the derived N,N′-disubstituted phenhomazines have been tested for
anticancer activity.
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