Synthesis, Characterization, and Anticancer Activity of NovelMacrocyclic Indenedione Based on the Tröger’s Base and N,N′-Disubstituted PhenhomazineCandidates

1,3-Indenedione has been reacted with p-aminobenzaldehyde to give the corresponding p-aminobenzylidine-1,3-indenedione, treatment of which with paraformaldehyde and trifluroacetic acid has led to the Troger’s base analogue. Treatment of that compound with dimethyl sulfate, acetic anhydride, benzoyl chloride, or trifluroacetic anhydride can afford the correspondingN,N′-disubstituted phenhomazines. Complexation of the Troger’s base with ferric nitrate trihydrate or nickel chloride hexahydrate has resulted in the corresponding complexes. The structures of all compounds have been confirmed by their elemental analyses and spectral data. All the newly synthesized Troger’s base and the derived N,N′-disubstituted phenhomazines have been tested for anticancer activity.