Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry

Steffen Lippold,Simone Nicolardi,Elena Domínguez-Vega,Anna-Katharina Heidenreich,Gestur Vidarsson,Dietmar Reusch,Markus Haberger,Manfred Wuhrer,David Falck

Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry

2019

Steffen Lippold
Simone Nicolardi
Elena Domínguez-Vega
Anna-Katharina Heidenreich
Gestur Vidarsson
Dietmar Reusch
Markus Haberger
Manfred Wuhrer
David Falck

AbstractDetermination of the impact of individual antibody glycoforms on FcɣRIIIa affinity, and consequently antibody-dependent cell-mediated cytotoxicity (ADCC), previously required high purity gl...

Keywords:

Monoclonal antibody
Molecular biology
Antibody-dependent cell-mediated cytotoxicity
Affinity chromatography
Antibody
Cytotoxicity
Critical quality attributes
Biochemistry
Mass spectrometry
Biology
Glycosylation

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