The changes of adipocytokines after surgery in OSAHS patients with insulin resistance

: Objective:To evaluate the changes of adipocytokines after surgery in OSAHS patients with insulin resistance.Method:Eighty-four OSAHS patients were enrolled in this study and divided into two group based on insulin resistance: IR group(n=52) and non-IR group(n=32). All patients received UPPP surgery. The levels of chemerin,visfatin and obestatin were measured before and one week after surgery.Result:Before surgery,the levels of chemerin,visfatin and HOMA-IR in IR group were higher than those in non-IR group,while level of obestatin was lower than those in non-IR group. One week after surgery,the level of obestatin in IR group was lower than those in non-IR group. The levels of chemerin,visfatin and HOMA-IR were decreased while obestatin increased after surgery. Correlation analysis showed that UPPP surgery was negatively related with △chemerin（r=-0.685，P<0.05）and △HOMA-IR（r=-0.622，P<0.05）.△HOMA-IR was positively associated with △chemerin（r=0.634，P<0.05）.Conclusion:The levels of chemerin,visfatin and obestatin are significantly improved after UPPP surgery. Level of chemerin seems to have a close relationship with IR.