Synthesis of new β-trifluoromethyl containing GABA and β-fluoromethyl containing N-benzylpyrrolidinones
2010
Abstract A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N -benzylpyrrolidinones 5a – c was synthesized by deoxyfluorination of corresponding 3-functionalized N -benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N -benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
32
References
16
Citations
NaN
KQI