Copper-Catalyzed Formation of α-Alkoxycycloalkenones from N-Tosylhydrazones
2015
The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The data suggests that this transformation occurs through cycloaddition of a copper carbenoid with an ester, followed by a Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
107
References
26
Citations
NaN
KQI