Expression of BCAN gene in clear renal cell carcinoma and its clinical significance

Objective To analyze the expression of BCAN gene in clear renal cell carcinoma(ccRCC)and its effect on the prognosis of patients. Methods The expression of BCAN in ccRCC in Oncomine database was explored. The clinical data and information about target gene expression of patients with ccRCC were obtained from the TCGA database for statistical analysis. Gene enrichment analysis was carried out using GSE73731 data set of clear renal cell carcinoma samples in GEO database. Protein related to BCAN was analyzed by String database. Results Among the patients with ccRCC, the patients with low BCAN expression were significantly lower than the high expression group in terms of pathological stage and T stage(P 0.05). The overall survival of patients in the low expression group of BCAN was better than that in the high expression group(P=0.033). The ccRCC samples in the high expression group of BCAN gene were mainly concentrated in KRAS signaling pathway. Conclusions BCAN can promote the invasive ability of tumor cells through various ways, which is expected to be one of the important biomarkers for the poor prognosis of ccRCC. Key words: Carcinoma, Renal Cell; Brevican