Microwave-assisted synthesis and in vitro antiproliferative activity of some novel 1,2,3-triazole-based pyrazole aldehydes and their benzimidazole derivatives

A series of new 3-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes 4(a–g) and their benzimidazole derivatives 6(a–g) were synthesized under both conventional and microwave irradiation methods. However, we successfully achieved good yields in shorter reaction times under microwave irradiation. All the synthesized scaffolds were characterized by 1H NMR, 13C NMR, IR and mass spectral analyses. The synthesized compounds have been evaluated as potential antiproliferative agents. The antiproliferative activity of the synthesized compounds was studied against two cancer cell lines C6 (nerve cells) and MCF-7 (human breast adenocarcinoma cells) and among them, compounds 4g and 6b exhibited highly potent activity against C6 cell line and 6b–c exhibited highly potent activity against MCF-7 cell line.