Plasma 9-cis,11-trans ve 10-trans, 12-cis Conjugated Linoleic Acid Isomers Levels in Continuous Ambulatory Peritoneal Dialysis Patients

ObJectIVe: Peritoneal dialysis is a renal replacement therapy in patients with end stage renal disease. Conjugated linoleic acid (CLA) refers to a class of positional and geometric conjugated isomers of the omega-6 essential fatty acid, linoleic acid. This study aimed to investigate biologically active isomers of CLA (10-trans, 12-cis CLA and -9-cis,11-trans CLA) and the relationship between these fatty acids and weight, body mass index (BMI), C-reactive protein (CRP) and parathyroid hormone (PTH) in continuous ambulatory peritoneal dialysis patients (CAPD) and healthy subjects. MAterIAl and MetHODS: This study was performed on 51 (21M, 30F) CAPD patients at least 6 months under dialysis, aged 20-75 years and 45 (25M, 20F) healthy control subjects aged 20-60 years. Plasma 10-trans, 12-cis CLA (t10,c12 CLA) and 9-cis,11-trans CLA (c9,t11 CLA) levels were measured by GS-MS technique. reSultS: t10,c12 and c9,t11 isomers of CLA levels of the CAPD patients were as follows: 11.84 ± 5.3 and 8.34 ± 4.4 mg/L respectively. The same parameters of the controls were as follows: 12.88 ± 4.1 and 9.20 ± 4.5 mg/L, respectively. The differences between plasma CLA isomers levels of CAPD doi: 10.5262/tndt.2012.1003.08 Yazisma Adresi: Fatma Humeyra YerlikAYA Necmettin Erbakan Universitesi, Meram Tip Fakultesi, Biyokimya Anabilim Dali, Konya, Turkiye Gsm : 0 505 466 42 31 E-posta : fhumeyray@hotmail.com Gelis Tarihi : 21.10.2011 Kabul Tarihi : 27.11.2011 Yerlikaya FH ve ark: Surekli Ayaktan Periton Diyalizi Hastalarinda Plazma 9-cis, 11-trans ve 10-trans, 12-cis Konjuge Linoleik Asit Izomerleri Duzeyleri 248 turk nefroloji Diyaliz ve transplantasyon Dergisi Turkish Nephrology, Dialysis and Transplantation Journal Turk Neph Dial Transpl 2012; 21 (3): 247-252 periton diyalizi (SAPD) hastalarinda ve saglikli kisilerde bu yag asit duzeylerini karsilastiran ve vucut kitle indeksi (VKI), C-reaktif protein (CRP) ve PTH ile iliskisini arastiran herhangi bir calismaya rastlanilmamistir. Biz bu calismada, SAPD hastalarinda ve saglikli kisilerde plazma c9,t11 KLA ve t10,c12 KLA izomerleri duzeylerini ve bu yag asitleri ile kilo, VKI, CRP, PTH arasindaki iliskiyi arastirmayi amacladik.