Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

Li Li,Yuan Liu,Hang-zi Chen,Feng-wei Li,Jianfeng Wu,Hongkui Zhang,Jian-ping He,Yong-zhen Xing,Yan Chen,Wei-jia Wang,Xu-yang Tian,An Zhong-li,Qian Zhang,Pei-Qiang Huang,Jiahuai Han,Tianwei Lin,Qiao Wu

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

2015

Li Li
Yuan Liu
Hang-zi Chen
Feng-wei Li
Jianfeng Wu
Hongkui Zhang
Jian-ping He
Yong-zhen Xing
Yan Chen
Wei-jia Wang
Xu-yang Tian
An Zhong-li
Qian Zhang
Pei-Qiang Huang
Jiahuai Han
Tianwei Lin
Qiao Wu

The orphan nuclear receptor Nur77 blocks inflammation through inhibition of p65 DNA binding and is suppressed by p38α-mediated phosphorylation. A small-molecule compound, PDNPA, disrupts p38α-Nur77 interactions and alleviates mouse models of sepsis.

Keywords:

Molecular biology
Inflammation
DNA
Nerve growth factor IB
Nuclear receptor
Sepsis
Phosphorylation
Transcription (biology)
p38 mitogen-activated protein kinases
Biology
Cell biology
Homeostasis

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