QSAR studies on phenoxyalkyl imidazoles as potent H3-receptor histamine antagonists

QSAR studies on a series of phenoxyalkyl imidazoles is attempted topologically using the negentropy (N), molecular redundancy (MRI), first-order valence connectivity ( 1 X v ) and Wiener (W) indices. The regression analysis of the data employing the multiple linear analysis and cross-validation method has indicated that MRI is the most suitable index for this purpose. The use of indicator parameters has finally demonstrated the need of substitution at 4-position in the phenyl ring for exhibition of H 3 -receptor antagonisms of the imidazoles used.