Changes and Significance of Serum IL-18,IL-6 and TNF-α in the Patients with Viral Myocarditis

Objective To explore the changes of serum interleukin-18(IL-18),interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) levels in the patients with viral myocarditis(VM) and their clinical significance.Methods Serum levels of IL-18,IL-6 and TNF-α were detected by ELISA in 48 cases with VM,and 30 normal healthy people as controls.CK-MB was also measured using an immune inhibitory method.Results Serum IL-18,IL-6,TNF-α and CK-MB levels of in VM group with the acute phase were significantly higher compared with those of VM group with recovery phase and control group(P0.01),however there was no significant difference in the serum IL-18,IL-6,TNF-α and CK-MB levels between VM Group with the recovery phase and control group(P0.05).There was positive correlation between IL-18,IL-6 and TNF-α and CK-MB in the patients with acute VM(P0.05).Conclusion Overexpression of IL-18,IL-6 and TNF-α may be heavily involved in the pathogenesis of VM,and their can be indicators for assessing severity and judging prognosis.