The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis

Objective: The interleukin (IL)-1 family and its related family members are primary inflammatory cytokines. The aim of this study was to assess the possible association between nine IL-1 family gene polymorphisms and rheumatoid arthritis (RA).Methods: To investigate the genetic association between IL-1 family gene polymorphisms and the risk of RA in a Korean population, 69 single nucleotide polymorphisms (SNPs) of the nine IL-1 family gene regions were selected. A total of 806 subjects (498 controls and 308 RA patients) were included in the study. The genotypes of the selected SNPs in the IL-1 family genes were determined using Illumina Sentrix Array Matrix chips. SNP Stats, Haploview, and SNP Analyzer, and Helixtree programs were used for the analysis of the genetic data.Results: We observed statistically significant associations between the SNPs of IL1F10 and IL1RN among the IL-1 family genes in the RA patients and the control population. When the patients were divided into two groups according to the p...