Оценка показателей иммунного ответа у больных с туберкулезом органов дыхания и оппортунистическими инфекциями

The purpose of the study: evaluation of the demographic, clinical and laboratory features of the patients with infiltrative, generalized and disseminated forms of tuberculosis. Materials and methods . 114 patients with pulmonary tuberculosis were included in our study. To evaluate subpopulations of immune cells we used immunofluorescent reaction with monoclonal antibodies. Results . Most of the patients with generalized and disseminated tuberculosis were co-infected with Human Immunodeficiency Virus with CD4+ level less than 200 cells/mkl and Hepatitis C Virus. Almost half of the patients with infiltrative and disseminated tuberculosis had elevated level of hepatic transaminases. In patients with generalized form of tuberculosis CD4+- and CD8+-levels were considerably lower than in patients with infiltrative form of tuberculosis. Discussion. In most patients with disseminated tuberculosis were estimated drug addict and prisons in anamnesis. In those patients were diagnosed secondary infections: candidiasis, papillomatosis, ascariasis, herpes zoster. Conclusions . We reveal decreasing of the level of CD4, CD8, CD16, CD20 in the patients with generalized, disseminated tuberculosis and in patients opportunistic infections.