Development of a One-Pot Four C–C Bond-Forming Sequence Based on Palladium/Ruthenium Tandem Catalysis
2018
A one-pot four C–C bond-forming sequence has been developed using two distinct transition metal complexes. The sequence entails a double Pd-catalyzed allylic alkylation followed by a Ru-catalyzed ring-closing metathesis and a Pd-catalyzed Heck coupling. The use of various active methylene nucleophiles was examined with yields up to 76% (93% per C–C bond).
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