OBESITY AND PROSTATE CANCER CLINICAL RISK FACTORS AT PRESENTATION: DATA FROM CaPSURE

ABSTRACTPurpose: We investigated the association of obesity with prostate cancer case demographics and clinical disease features at presentation.Materials and Methods: Data were abstracted from CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor), a disease registry of 10,018 men with prostate cancer. A total of 2,952 men were included who were treated between 1989 and 2002, and had complete body mass index (BMI) information. BMI classes were defined as normal (less than 25 kg/m2), overweight (25 to 29.9 kg/m2), obese (30 to 34.9 kg/m2) or very obese (35 kg/m2 or greater). Patients were categorized as having low, intermediate or high risk disease based on the D’Amico classification. Associations among BMI, risk and demographics were analyzed using univariate and multivariate models.Results: Of the patients 29% had a normal BMI, 51% were overweight, 16% were obese and 5% were very obese. Patients who were overweight or obese were more likely to be young, have hypertension and diabetes, and...