Function and design of the Nox1 system in vascular smooth muscle cells

Background Recent studies have demonstrated that the activation of NADPH oxidase 1 (Nox1) plays an important role in the control of reactive oxygen species and their involvement in vascular physiology and pathophysiology. In order to function properly, Nox1 needs to be available in an optimal state, where it is ready to respond appropriately and efficiently to upstream signals. It must also be able to return quickly to this state as soon as the input signal disappears. While Nox1 activation has been discussed extensively in recent years, mechanisms for enzyme disassembly and proper subunit recovery have not received the same attention and therefore require investigation.