Assessment of Cytochrome P450 3A4 Activity During the Menstrual Cycle Using Alfentanil as a Noninvasive Probe

Background:Gender-dependent differences in cytochrome P450 activity, drug metabolism, drug elimination, and their clinical consequences are increasingly apparent. P450 3A4 is the most abundant P450 isoform in the human liver and is responsible for metabolizing a vast and diverse assortment of therap