Neurocognitive sequelae following hippocampal and callosal lesions associated with cerebral malaria in an immune-naive adult

Cerebral malaria, a diffuse encephalopathy caused by Plasmodium falciparum , is associated with long-term neurocognitive impairments.1 ,2 P falciparum remains the most common parasitic infection of the central nervous system with characteristic clinico-radiological manifestations . Over two billion people are affected by malaria each year, with mortality of over one million.1 It has been estimated that between 5% and 26% of affected children have cognitive impairment.1 ,2 The prevalence of cognitive impairment in adults is not known, primarily due to a lack of long-term follow-up studies. We report a case of a 36-year-old immune-naive Caucasian female who sustained a brain injury with neurocognitive sequelae, after a severe bout of falciparum malaria. On admission, she was unconscious, febrile, …