Institutional report - Cardiac general Effect of melatonin in the prevention of postoperative pericardial adhesion formation

To evaluate the efficacy of melatonin in preventing postoperative pericardial adhesions, 12 single breed dogs were randomized equally into experimental (melatonin) and control groups. After ketamine anesthesia, a vertical midsternal incision was done and the parietal pericardium of the inferior site of the heart was opened vertically. To promote adhesion formation, abrasions were created on both parietal and visceral pericardial surfaces in an area of 2 cm with two vertically reciprocal movements of dry gauze. In the melatonin group, 5% 2