Intraoperative Floppy Iris Syndrome Associated with α1-Adrenergic Receptor Antagonists

OBJECTIVE:To describe intraoperative floppy iris syndrome (IFIS) in association with α1-adrenergic receptor (α1AR) antagonists by conducting a thorough literature review.DATA SYNTHESIS:Literature retrieval was accomplished by searching MEDLINE (2000–December 2007) using the terms intraoperative floppy iris syndrome (IFIS), adrenergic α-antagonist(s), tamsulosin, doxazosin, terazosin, and/or alfuzosin. In addition, reference lists from identified publications were reviewed to identify additional reports and studies of interest.STUDY SELECTION AND DATA EXTRACTION:All articles in English identified from data sources were reviewed for relevance and uniqueness prior to inclusion.DATA SYNTHESIS:IFIS was first described in 2005 as a clinical triad observed during cataract surgery that includes fluttering and billowing of the iris stroma, propensity for iris prolapse, and constriction of the pupil. IFIS increases the risk of complications during cataract surgery. Numerous reports have linked IFIS to use of α1AR a...