The influence of xinfeng capsule on the cardiac function and cytokines in adjuvant arthritis rats.

Objective To study the influence of Xinfeng capsule(XFC) on the cardiac function,regulate T cells(Treg) and cytokines(TNF-α,IL-17,BNP,IL-10)in adjuvant arthritis(AA) rats.Method 60 rats were averagely divided into normal control group(NC),model control group(MC),methotrexate(MTX)treated group,tripterygium glycosides tablet(TGT) treated group,XFC treated group,12 in each.Except for the rats of normal group,the others were intracutaneously injected with 0.1 ml of Freund's complete adjuvant(FCA) in the right hindlimb.After 19 days,NC group and MC were given normal saline,the other three groups were given MTX,TGT,XFC.All of the indexes were investigated in different groups.Results 1.When compared with the MC group,the LVSP,LVEDP(P0.05)and ±dp/dtmax of XFC group were significantly lower(P0.05).When compared with the XFC group,the LVSP,LVEDP MTX of group were significantly higher(P0.05).However the±dp/dtmax of MTX group was significantly lower(P0.05).2.When compared with the XFC group,the TNF-α、IL-17、BNP were lower than that of MC group(P0.01).However the IL-10,CD4+Treg and CD4+CD25+Treg were higher than that it(P0.01).But there were no obvious differences between the two treated groups(P0.05).Conclusion There were cardiac functional impairment in AA rats.Not only XFC can improve paw swelling and arthritis index,but also improve cardiac function of AA rats,which may be related to its role in regulating the abnormal immune respouses.XFC can regulate the immune response while inhibite abnormal inflammatory of immune responses which could damage myocardial cell.