The Healing Effect of Platelet-rich Plasma (PRP) Jelly in Rabbits Undergoing Tracheal Resection and Anastomosis

BACKGROUND/AIM: Tracheal anastomosis is commonly indicated for patients with tracheal tumor, stenosis and tracheoesophageal fistula. This study was designed to evaluate the healing activity of topical application of platelet-rich plasma (PRP) jelly for tracheal reconstruction in a rabbit model. MATERIALS AND METHODS: Thirty-six healthy New Zealand White rabbits were assigned to three groups of 12 animals each. The control group underwent tracheal resection and anastomosis. The fibrin-glue group and PRP-jelly group underwent tracheal resection and anastomosis plus fibrin glue or PRP jelly application over the anastomosis and surgical field, respectively. RESULTS: The PRP jelly treatment enhanced the healing capacity by positive effects on healing rate, tissue fill, and volume fraction of fibroblasts during the 28 days following surgery. CONCLUSION: Application of PRP jelly to tracheal anastomotic wounds can accelerate or improve the quality of repair.