Formulation and Evaluation of Torsemide intragastric buoyant sustained release

The present study describes a gastroretentive floating controlled drug delivery system containing torsemide in the form of microsphere prepared by ionic gelation technique and evaluated for its processing parameters. Nine formulations containing retardant material such as sodium alginate and HPMC K15, foam forming agent sodium bicarbonate were prepared loaded with torsemide. Solid, discrete and reproducible free flowing microspheres were obtained. The microspheres had almost smooth surface with free flowing and good packing properties. The micromeretic study indicated that the obtained angle of repose, % compressibility index values were lie with in the limit.The prepared microspheres were characterized for their entrapment efficiency, particle size, floating ability, in-vitro release behavior, scanning electron microscopy (SEM) and differential scanning calorimeter (DSC).The in-vitro dissolution studies were carried out in the USP dissolution Apparatus-2 in 0.1N HCl at 50 rpm at 37±0.5 °C. Microspheres remain buoyant over a period of 8hrs in the release medium and the amount of sodium bicarbonate was found to be significant for remaining buoyant. It was found that the torsemide floating microspheres can be successfully prepared having high entrapment efficiency and prolonged released behavior with a substantial floating ability.