[Research progress of N-Myc roles in hematopoiesis and hematologic malignancies].

N-Myc oncogene plays an important role in the process of hematopoietic cell proliferation and differentiation in embryos.Once the body suffers from hematologic malignancies,the expression of N-Myc would increase and significantly associate with disease progression.In this artical the structure of N-Myc,the regulatory mechanism in the different hematopoietic lineages,the interaction in each signal pathways,the transgenic animal model of overexpression,and intervention by drugs are reviewed.