Elephant foot yam ameliorates activities of intestinal and renal disaccharidases in streptozotocin induced diabetic rats
2012
Elephant foot yam (Amorphophallus paeoniifolius (Dennst.) Nicolson syn.
Amorphophallus campanulatus) is a tuber vegetable used as an ingredient in
ayurvedic preparations for various ailments. The present investigation deals
with the effect of elephant foot yam extract on intestinal and renal disaccharidases
in normal rats and streptozotocin induced diabetic rats. The specific
activities of maltase, sucrase and lactase were measured in control and
starch fed diabetic (SFD), elephant foot yam extract at 0.1% fed diabetic
(YFD0.1), elephant foot yam extract at 0.25% fed diabetic (YFD0.25) and aminoguanidine
fed diabetic (AFD) groups at the end of experimental period. Intestinal
maltase, sucrase and lactase activities were high in SFD group compared
to control, YFD0.1, YFD0.25 and AFD groups. Amelioration of intestinal
maltase activities by 18% 26% and 48% was observed in YFD0.1, YFD0.25 and
AFD groups respectively when compared to SFD group. Intestinal sucrase
activity was ameliorated in YFD0.1, YFD0.25 and AFD groups to about 28%, 45%
and 56% respectively. Lactase activity of intestine was improved by 36%,
52% and 64% in YFD0.1, YFD0.25 and AFD groups respectively. On the contrary,
specific activities of renal maltase, sucrase and lactase were decreased in
SFD group compared to control groups. Supplementation of elephant foot
yam extract in diet significantly ameliorated renal disachharidases activities
in YFD0.1 and YFD0.25 groups. The results demonstrate the potential use of
elephant foot yam for the management of diabetes.
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