Association of FTO and IRX3 genetic variants to obesity risk in north India

AbstractBackground: Obesity is an increasingly important health problem worldwide as well as in developing countries like India. Recent genetic studies suggest that obesity associated FTO and IRX3 are functionally linked and many effects due to genetic variants in FTO gene act through IRX3.Aim: To evaluate the association of FTO and IRX3 genetic variants towards obesity risk.Subjects and methods: North Indian individuals categorised as non-obese (BMI < 30 kg/m2) and obese (BMI ≥ 30 kg/m2) were selected. FTO rs8050136, rs1421085, rs9939609, rs17817449 and IRX3 rs3751723 were genotyped by means of validated Taqman® allelic discrimination to evaluate their association with obesity by means of single locus logistic regression by SPSS ver. 19 and multi-locus linkage and haplotype analysis by SNPStats and gene–gene interaction with Generalised Multifactor Dimensionality Reduction (GMDR) ver.6.Results: In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7–3.4) and AA (p = 0.0001; OR (95%...