Delayed-Type Hypersensitivity

Binding of TNF-α to its receptors results in trimerization via intracellular death domains (DD). This leads to the docking of adapter proteins also containing DD. Adapter proteins include TNF-R1-associated deathdomain-containing factor (TRADD), Fas-associated death-domain-containing protein (FADD), and TNFR-associated factor-2 (TRAF2). This complex serves to recruit and activate other accessory proteins with catalytic activity including various kinases and proteases. These enzymes function to activate the various signaling pathways culminating in cell death and/ or cell survival. Tumor Necrosis Factor-α