KLK3 gene rs266882 polymorphism in prostatic tissue

Introduction: Prostate cancer is one of most frequent neoplasia in males, affecting the majority of men in the eighth decade of life. It is not yet known what specifically causes prostate cancer, but there are several risk factors for the disease, including age or diet, and it is known that different populations have different risk of developing this cancer. For instance, men in developed countries have higher risk to get this neoplasia and mortality rate is higher in black men, according International Agency for Research on Cancer 2012 data. Prostate cancer can often be detected before symptoms start by testing the amount of prostate-specific antigen (PSA) and is variant forms in a man’s blood. However, high levels of this protein do not mean malignancy. So, new biomarkers of this cancer are need. In order to learn more about prostate cancer, we aim to analyze the frequency of ARE-I polymorphism at -158 position of the KLK3 gene in prostatic tissue and the results were compared with other populations fre...