Computerized analysis of the relationship between allergenicity of microorganisms and their habitats

The incidence of allergic diseases in the 20th century has rapidly increased. Currently, many people in industrial countries suffer from allergies, which makes analysis of the allergenic properties of proteins an urgent problem. Earlier, it was assumed that the allergenicity of proteins depends on their size, enzymatic properties, homology to human proteins, etc. However, no analysis of the relationship between the allergenicity of proteins and the habitat of the organisms producing them has been conducted as of yet. We have predicted the allergenic proteins from proteomes of more than 500 species of microorganisms. It is shown that the number of allergenic proteins in the proteomes of microorganisms is significantly related to their pathogenicity, habitats, ambient temperature conditions, and oxygen demands of these microorganisms.