TETRABROMOBISPHENOL A AND PHENOLIC XENO-ESTROGENS LEVELS IN INDOOR AIR

Recently a part of chemicals has attracted a great deal of public attention in Japan which are xenoestrogens as TBBPA, BPA, 4-tert-octylphenol (OP), 4-nonylphenol (NP) and pentachlorophenol (PCP). In the reason, these chemicals have been stayed behind in our life and environment and have a very weak effect for the estrogen response and in vivo assay. Take our investigations and studies of the residual existence in our life, trace and high levels of these chemicals were detected. Our studies for monitoring of endocrine disruptors in our life were achieved by the Health Sciences Researches project (1999-2001: a head researcher, PhD. Nakazawa, H.) from the Ministry of Health, Labour and Welfare of Japan. In this a part of researches, the human exposures to TBBPA, BPA, OP, NP and PCP were investigated by the analytical methods for determination of these chemicals in human biological samples. These results shown that very trace levels of some chemicals or metabolites were detected in some human blood or urine sample. Thus, we must make sure the source of these detected chemicals in human biological samples. Recently many sources of human exposure to these compounds have been existed. High risk factors are some routes by every foods, drink water and indoor air. Therefore, the present study indicates to investigate and evidence of environmental exposure and risk assessment of these compounds as TBBPA in indoor air of Tokyo, Japan. In addition, this approach employed liquid chromatography with an electrospray mass spectrometric detector (LC-MS) and the sampling correction using the stable isotopically labeled internal standards for the sensitive, selective and accurate determination of TBBPA and xeno-estrogens in air sample. This proposed method was