computed tomographic coronary angiography after a single radiation exposure from 64-slice Estimates of lifetime attributable risk of cancer

1ABSTRACTAims To estimate the life attributable risk (LAR) of cancerincidence over a wide range of dose radiation exposureand a large spectrum of possible diagnostic computedtomographic coronary angiography (CTCA) scenarios.Methods This study included 561 consecutive patientswho underwent a successful prospective ECG-gatingCTCA protocol (low-dose group) 64-slice CTCA and 188patients who underwent retrospective ECG-gating CTCAwith ECG-triggered dose modulation CTCA (high-dosegroup). LAR was computed, given the organ equivalentdose, for all cancers in both sexes. LAR was tabulatedfor each decile of dose-length product by 10-year ageclasses, separately for each sex.Results Estimates of LAR of any cancer for an exposureat age #40 year were lower in males than in females forany given quantile. At age $50years, LAR was similarbetween sexes only at the lowest exposure doses,whereas at higher dosage, it was, in general, higher forwomen. At the median age of this case series (62 years)and for a radiation exposure ranging from 1.33 to3.81 mSv, LAR was 1 in 4329 (or 23.1 per 10