Directed Alkynylation of Unactivated C(sp3)-H Bonds with Ethynylbenziodoxolones Mediated by DTBP.

A general and efficient method for the direct alkynylation of unactivated C(sp3)–H bonds under metal-free conditions is described. The reaction performs smoothly under mild conditions and shows excellent functional-group tolerance. Initial mechanistic investigation indicates that the reaction may involve a radical pathway.