Evaluation of Hepatoprotective Activity of Bauhinia purpurea Linn

Present study was carried out to investigate different extracts of Bauhinia purpurea (B.P) for its hepatoprotective activity against CCl4 induced hepatotoxicity. Mature leaves of Bauhinia purpurea were collected, authenticated and was subjected to extraction using different solvents like chloroform, alcohol and water. Healthy wistar albino rats (150-200g) of male sex were used for the in-vivo investigations. Liver damage was induced by administration of 30% CCl4 suspended in olive oil (1ml/kg body weight). Activities of liver marker enzymes, glutamate oxaloacetate transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), acid phosphatase (AP), alkaline phosphatase (ALP),total albumin(TA), total bilirubin(TB), Total protein(TP), direct bilirubin (DB) at a dose of aqueous extract of leaves (100 mg/kg) chloroform extract of leaf of B.P (100mg/kg and 150 mg/kg) and ethanol extract of leaf of B.P (100mg/kg and 150 mg/kg) showed a significant hepatoprotective effect in comparison with the standard (sylimarin). It is also confirmed by liver histopathology of treated animals. The present study demonstrated the extracts of B.P have hepatoprotective effect against CCl4 induced hepatotoxicity.