CLINICAL ADVANCES IN LIVER, PANCREAS, AND BILIARY TRACT HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

This article has an accompanying continuing medical education activity on page e9. Learning Objective: Upon completion of reading this article, successful learners will be able to differentiate the effect of different patterns of iron overload on liver damage, understand the effect of mutations in the HFE gene of hereditary hemochromatosis in determining the predisposition to develop iron overload, and recognize the lack of utility of HFE mutations assessment in the absence of histological demonstration of hepatocellular iron accumulation in patients with nonalcoholic fatty liver disease.