Heteroaromatic side-chain analogs of pregabalin

Robert Michael Schelkun,Po-Wai Yuen,David Juergen Wustrow,Jack J. Kinsora,Ti-zhi Su,Mark G. Vartanian

Heteroaromatic side-chain analogs of pregabalin

2006

Robert Michael Schelkun
Po-Wai Yuen
David Juergen Wustrow
Jack J. Kinsora
Ti-zhi Su
Mark G. Vartanian

A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.

Keywords:

Side chain
Pregabalin
Organic chemistry
Stereochemistry
Biochemistry
Chemistry
thiophene derivatives
Chemical synthesis
Anticonvulsant

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