Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells

Il-Kyu Kim,Byung Seok Kim,Choong-Hyun Koh,Jae-Won Seok,Jun-Seok Park,Kwang Soo Shin,Eun-Ah Bae,Ga-Eun Lee,Hyewon Jeon,Jaebeom Cho,Yujin Jung,Daehee Han,Byoung S. Kwon,Ho-Young Lee,Yeonseok Chung,Chang-Yuil Kang

Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells

2015

Il-Kyu Kim
Byung Seok Kim
Choong-Hyun Koh
Jae-Won Seok
Jun-Seok Park
Kwang Soo Shin
Eun-Ah Bae
Ga-Eun Lee
Hyewon Jeon
Jaebeom Cho
Yujin Jung
Daehee Han
Byoung S. Kwon
Ho-Young Lee
Yeonseok Chung
Chang-Yuil Kang

GITR signaling inhibits tumor growth by inducing TH9 cell differentiation, increasing IL-9–dependent dendritic cell function and enhancing cytotoxic T cell responses.

Keywords:

Virology
Dendritic cell
Co-stimulation
Immunology
Glucocorticoid-Induced TNFR-Related Protein
Cellular differentiation
Lymphocyte differentiation
Cytotoxic T cell
Interleukin 9
NFKB1
Biology
T cell

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