MESENTERIC HETEROTOPIC OSSIFICANS IN A FERRET (MUSTELA PUTORIOUS FURO): A RARE CAUSE OF SOFT TISSUE OSSIFICATION

Abstract Heterotopic ossification (HO) is a rare condition characterised by abnormal bone production in soft tissue. Very few cases of HO have been reported in animals (e.g., dogs, horses) and often this disease process is a consequence of a traumatic incident. A 5-year-old, male European ferret ( Mustela putorious furo ) was referred for anorexia, generalised weakness and weight loss. Clinical examination revealed multiple abdominal masses. An explorative laparotomy identified omental, white/tan, nodular to coalescing hard lesions. The omentum and spleen were surgically removed during the surgical procedure, with both subsequently submitted for histopathologic evaluation. Microscopically, the omental masses were composed of a meshwork of lamellar and woven bone admixed with islands of cartilage and lacunae containing either blood, fat and/or bone marrow. Multifocal mineralisation and bone lamellae were also present in the grossly normal omentum. The finding of multiple bone nodules containing bone marrow and/or adipose tissue, with no Harversian system, and minimal intra-trabecular connective tissue favored a diagnosis of HO.