Synthesis of oligosaccharides with oligoethylene glycolspacers and their conversion into glycoconjugates usingN,N,N ′ ,N ′ -tetramethyl(succinimido)u roniu mtetrafluoroborate as coupling reagent

Glycosides of glucose and lactose with di- and tetraethylene glycols, transformed into bifunctional (alcohol, ester) spacer molecules, have been synthesized. After deprotection, these spacer glycosides, containing a free carboxyl group, have been transformed efficiently into glycoconjugates usingN,N,N′,N″-tetramethyl(succinimido)uronium tetrafluoroborate (TSTU) for the formation of an active ester.