International AS Registry: The Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance Initiative

In August 2014, the Movember Foundation launched the Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative. This global project aims to create the largest centralized prostate cancer active surveillance database to date, comprising the majority of the world’s organized active surveillance patient data. This database will be used to optimize the management of men diagnosed with low-risk prostate cancer and reduce the burden of overtreatment in men with truly low-risk disease. Milestones of the project include the development of worldwide uniform guidelines on active surveillance and a web-based platform with information and guidelines on AS. The Movember Foundation has utilized its global networks and unique position as a multinational, large-scale funder of prostate cancer, testicular cancer, and suicide prevention programs, to unite clinicians and researchers from around the globe. To date, the GAP3 initiative includes 30 partners in 15 countries across five Movember regions (Australasia, Europe, UK, Canada, USA). Additional funding has been allocated to sustain the database, with a special focus on the role of MRI and genomic testing for the future management of active surveillance. GAP3 is the largest effort of its type to integrate patient data from men with prostate cancer on active surveillance protocols and provides a legal and technical framework for future projects to safely share data. The GAP3 project will allow patients and clinicians to have greater confidence in the decision to either delay or proceed with active treatment based on analyses and clinical guidelines from global and up-to-date data. The project provides an important opportunity to improve the lives of men diagnosed with low-risk prostate cancer.