Effects of long-term chronic moderate-exercise training on renal-protection in 5/6 nephrectomized spontaneously hypertensive rats

Objective:To determine whether long-term chronic moderate-Ex training worsing renal function and whether long-term chronic moderate-Ex training providing a renal protective effect to in this rat model.Method:Eight-week-old spontaneously hypertensive rats(SHR) were subjected to 5/6 nephrectomy by removal of the left kidney and infarction of two thirds of the right kidney. The SHR was divided into 2 group:a remained sedentary group (sedentary) and a group conducting moderate treadmill running at 20m/mim 0° for 60min(exercise) 5 times/week for 8 weeks.Result: Long-term chronic moderate-Ex training furthermore significantly attenuated the increase in proteinuria and less serum total cholesterol levels. In addition, index of glomerular sclerosis(IGS) and serum creatinine was notably significantly reduced by exercise.Conclusion:Those effects of long-term chronic moderate-Ex training on renal-protection is also possible in this rat model.