Fundamental kinematics laws of interstitial fluid flows on vascular walls

Abstract In the previous studies, the phenomenon that the interstitial fluid (ISF) can flow along tunica adventitia of the arteries and veins in both human and animal bodies was reported. On the basis of these studies, this paper aims to: (i) summarize the basic properties of the ISF flows in the walls of arteries and veins, (ii) combine the basic properties with axiomaticism and abstract the axiom for ISF flows, and (iii) propose three fundamental laws of the ISF flow, (i.e., the existence law, the homotropic law and the reverse law). The three laws provide solid theoretical basement for exploring the kinematic patterns of interstitial fluid flow in the cardiovascular system.